WB analysis of HeLa cell lysate using GTX30125 NBS1 antibody.
WB analysis of HeLa cell lysate using GTX30125 NBS1 antibody.
NBS1 antibody
GTX30125
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetNBN
Overview
- SupplierGeneTex
- Product NameNBS1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:1000. ICC/IF: 1:50 - 1:200. IHC-P: 1:100 - 1:200. IP: 3 ul. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID4683
- Target nameNBN
- Target descriptionnibrin
- Target synonymsATV; AT-V1; AT-V2; cell cycle regulatory protein p95; NBS; NBS1; nibrin; Nijmegen breakage syndrome 1 (nibrin); P95; p95 protein of the MRE11/RAD50 complex
- HostRabbit
- IsotypeIgG
- Protein IDO60934
- Protein NameNibrin
- Scientific DescriptionMutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq]
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex. Ge C et al., 2015, PLoS OneRead more
- BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Ge C et al., 2015 Mar 17, Proc Natl Acad Sci U S ARead more
- Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients. Siwicki JK et al., 2003 Jul 1, Exp Cell ResRead more
- Blooms syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. Franchitto A et al., 2002 Apr 1, J Cell BiolRead more
- Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome. Harfst E et al., 2000 Oct, Mol ImmunolRead more
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