NBS1 antibody

GTX30125

ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHamster, Human, Mouse, Primate

TargetNBN

Overview

Supplier
GeneTex
Product Name
NBS1 antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000. ICC/IF: 1:50 - 1:200. IHC-P: 1:100 - 1:200. IP: 3 ul. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID4683
Target name
NBN
Target description
nibrin
Target synonyms
AT-V1, AT-V2, ATV, NBS, NBS1, P95, hNbs1, nibrin, Nijmegen breakage syndrome 1 (nibrin), cell cycle regulatory protein p95, p95 protein of the MRE11/RAD50 complex
Host
Rabbit
Isotype
IgG
Protein IDO60934
Protein Name
Nibrin
Scientific Description
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq]
Reactivity
Hamster, Human, Mouse, Primate
Storage Instruction
2°C to 8°C
UNSPSC
12352203

References

Ge C, Che L, Du C. The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex. PLoS One. 2015,10(12):e0144957. doi: 10.1371/journal.pone.0144957
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Ge C, Che L, Ren J, et al. BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Proc Natl Acad Sci U S A. 2015,112(11):E1210-9. doi: 10.1073/pnas.1418335112
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Siwicki JK, Degerman S, Chrzanowska KH, et al. Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients. Exp Cell Res. 2003,287(1):178-89.
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Franchitto A, Pichierri P. Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. J Cell Biol. 2002,157(1):19-30.
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Harfst E, Cooper S, Neubauer S, et al. Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome. Mol Immunol. 2000,37(15):915-29.
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NBS1 antibody

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