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WB analysis of HeLa cell lysate using GTX30125 NBS1 antibody.
WB analysis of HeLa cell lysate using GTX30125 NBS1 antibody.
WB analysis of HeLa cell lysate using GTX30125 NBS1 antibody.

NBS1 antibody

GTX30125
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHamster, Human, Mouse, Primate
TargetNBN
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Overview

  • Supplier
    GeneTex
  • Product Name
    NBS1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000. ICC/IF: 1:50 - 1:200. IHC-P: 1:100 - 1:200. IP: 3 ul. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID4683
  • Target name
    NBN
  • Target description
    nibrin
  • Target synonyms
    AT-V1, AT-V2, ATV, NBS, NBS1, P95, hNbs1, nibrin, Nijmegen breakage syndrome 1 (nibrin), cell cycle regulatory protein p95, p95 protein of the MRE11/RAD50 complex
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO60934
  • Protein Name
    Nibrin
  • Scientific Description
    Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq]
  • Reactivity
    Hamster, Human, Mouse, Primate
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116161

References

  • The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex. Ge C et al., 2015, PLoS One
    Read this paper
  • BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Ge C et al., 2015 Mar 17, Proc Natl Acad Sci U S A
    Read this paper
  • Blooms syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. Franchitto A et al., 2002 Apr 1, J Cell Biol
    Read this paper
  • Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome. Harfst E et al., 2000 Oct, Mol Immunol
    Read this paper

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