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ICC/IF analysis of PFA fixed U2OS cells using GTX89962 nNOS antibody, C-term. Green : Primary antibody Blue : DAPI Permeabilization : 0.15% Triton Dilution : 10microg/ml
ICC/IF analysis of PFA fixed U2OS cells using GTX89962 nNOS antibody, C-term. Green : Primary antibody Blue : DAPI Permeabilization : 0.15% Triton Dilution : 10microg/ml
ICC/IF analysis of PFA fixed U2OS cells using GTX89962 nNOS antibody, C-term. Green : Primary antibody Blue : DAPI Permeabilization : 0.15% Triton Dilution : 10microg/ml

nNOS antibody, C-term

GTX89962
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetNOS1
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Overview

  • Supplier
    GeneTex
  • Product Name
    nNOS antibody, C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    IHC-P: 5microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.50 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4842
  • Target name
    NOS1
  • Target description
    nitric oxide synthase 1
  • Target synonyms
    IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, nitric oxide synthase 1, NOS type I, constitutive NOS, neuronal NOS, nitric oxide synthase 1 (neuronal), peptidyl-cysteine S-nitrosylase NOS1
  • Host
    Goat
  • Isotype
    IgG
  • Protein IDP29475
  • Protein Name
    Nitric oxide synthase 1
  • Scientific Description
    The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5 UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Zaninelli TH, Mizokami SS, Bertozzi MM, et al. Kaurenoic Acid Reduces Ongoing Chronic Constriction Injury-Induced Neuropathic Pain: Nitric Oxide Silencing of Dorsal Root Ganglia Neurons. Pharmaceuticals (Basel). 2023,16(3). doi: 10.3390/ph16030343
    Read this paper
  • Aktar R, Parkar N, Stentz R, et al. Human resident gut microbe Bacteroides thetaiotaomicron regulates colonic neuronal innervation and neurogenic function. Gut Microbes. 2020,11(6):1745-1757. doi: 10.1080/19490976.2020.1766936
    Read this paper
  • DiCello JJ, Carbone SE, Saito A, et al. Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon. Cell Mol Gastroenterol Hepatol. 2020,9(3):465-483. doi: 10.1016/j.jcmgh.2019.11.006
    Read this paper
  • DiCello JJ, Rajasekhar P, Eriksson EM, et al. Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon. Am J Physiol Gastrointest Liver Physiol. 2019,317(2):G79-G89. doi: 10.1152/ajpgi.00085.2019
    Read this paper
  • DiCello JJ, Saito A, Rajasekhar P, et al. Agonist-dependent development of delta opioid receptor tolerance in the colon. Cell Mol Life Sci. 2019,76(15):3033-3050. doi: 10.1007/s00018-019-03077-6
    Read this paper