
ICC/IF analysis of PFA fixed U2OS cells using GTX89962 nNOS antibody, C-term. Green : Primary antibody Blue : DAPI Permeabilization : 0.15% Triton Dilution : 10microg/ml
nNOS antibody, C-term
GTX89962
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetNOS1
Overview
- SupplierGeneTex
- Product NamenNOS antibody, C-term
- Delivery Days Customer9
- Application Supplier NoteIHC-P: 5microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.50 mg/ml
- ConjugateUnconjugated
- Gene ID4842
- Target nameNOS1
- Target descriptionnitric oxide synthase 1
- Target synonymsIHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, nitric oxide synthase 1, NOS type I, constitutive NOS, neuronal NOS, nitric oxide synthase 1 (neuronal), peptidyl-cysteine S-nitrosylase NOS1
- HostGoat
- IsotypeIgG
- Protein IDP29475
- Protein NameNitric oxide synthase 1
- Scientific DescriptionThe protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5 UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Zaninelli TH, Mizokami SS, Bertozzi MM, et al. Kaurenoic Acid Reduces Ongoing Chronic Constriction Injury-Induced Neuropathic Pain: Nitric Oxide Silencing of Dorsal Root Ganglia Neurons. Pharmaceuticals (Basel). 2023,16(3). doi: 10.3390/ph16030343Read this paper
- Aktar R, Parkar N, Stentz R, et al. Human resident gut microbe Bacteroides thetaiotaomicron regulates colonic neuronal innervation and neurogenic function. Gut Microbes. 2020,11(6):1745-1757. doi: 10.1080/19490976.2020.1766936Read this paper
- DiCello JJ, Carbone SE, Saito A, et al. Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon. Cell Mol Gastroenterol Hepatol. 2020,9(3):465-483. doi: 10.1016/j.jcmgh.2019.11.006Read this paper
- DiCello JJ, Rajasekhar P, Eriksson EM, et al. Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon. Am J Physiol Gastrointest Liver Physiol. 2019,317(2):G79-G89. doi: 10.1152/ajpgi.00085.2019Read this paper
- DiCello JJ, Saito A, Rajasekhar P, et al. Agonist-dependent development of delta opioid receptor tolerance in the colon. Cell Mol Life Sci. 2019,76(15):3033-3050. doi: 10.1007/s00018-019-03077-6Read this paper







