![GTX84019 IHC-P Image GTX84019 IHC-P Image](https://www.genetex.com/upload/website/prouct_img/normal/GTX84019/GTX84019_2164_IHC-P_18121411_212.jpg)
GTX84019 IHC-P Image
NOTCH1 antibody [3E12] - KO/KD, Overexpression Validated
![Research Use Only](static/images/certificates/ruo.jpg)
GTX84019
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
Overview
- SupplierGeneTex
- Product NameNOTCH1 antibody [3E12] - KO/KD, Overexpression Validated
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Concentration0.2 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionFunctions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia.
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203