GTX28925 IHC-P Image
NOTCH1 antibody
GTX28925
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman, Mouse, Rat
Overview
- SupplierGeneTex
- Product NameNOTCH1 antibody
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration78 mg/ml
- HostRabbit
- IsotypeIgG
- Scientific DescriptionNotch 1 is synthesized in the endoplasmic reticulum as an inactive form, which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- MicroRNA-223-induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways. Liu Z et al., 2021 Feb, Mol Med RepRead more
- Notch 1 signaling pathway effect on implantation competency. Chu PW et al., 2011 Nov, Fertil SterilRead more
- Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Cheng X et al., 2008 Oct, DevelopmentRead more
- Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy. Nwabo Kamdje AH et al., 2012 May, Blood Cancer JRead more