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Oct4 antibody [GT486]

Name: Oct4 antibody [GT486]
SKU: GTX627419_G10
Availability: BackOrder

GTX627419

ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetPOU5F1

Overview

Supplier
GeneTex
Product Name
Oct4 antibody [GT486]
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. FACS: 1:50-1:200. IP: 1:1000-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
GT486
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID5460
Target name
POU5F1
Target description
POU class 5 homeobox 1
Target synonyms
OCT3, OCT4, OCT4Borf1, OTF-3, OTF3, OTF4, Oct-3, Oct-4, Oct3/4, POU domain, class 5, transcription factor 1, POU domain transcription factor OCT4, POU-type homeodomain-containing DNA-binding protein, octamer-binding protein 3, octamer-binding protein 4, octamer-binding transcription factor 3
Host
Mouse
Isotype
IgG2a
Protein IDQ01860
Protein Name
POU domain, class 5, transcription factor 1
Scientific Description
This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewings sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Heparanase regulates EMT and cancer stem cell properties in prostate tumors.
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Selective Proliferation of Highly Functional Adipose-Derived Stem Cells in Microgravity Culture with Stirred Microspheres. Mashiko T et al., 2021 Mar 4, Cells
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Upregulation of CD109 Promotes the Epithelial-to-Mesenchymal Transition and Stemness Properties of Lung Adenocarcinomas via Activation of the Hippo-YAP Signaling. Lee KY et al., 2020 Dec 25, Cells
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The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells. Andreucci E et al., 2020 Oct, J Mol Med (Berl)
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From ACTH-Dependent to ACTH-Independent Cushings Syndrome from a Malignant Mixed Corticomedullary Adrenal Tumor: Potential Role of Embryonic Stem Cells. Ramirez-Renteria C et al., 2020, Case Rep Endocrinol
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Mitochondrial DNA alterations may influence the cisplatin responsiveness of oral squamous cell carcinoma. Aminuddin A et al., 2020 May 12, Sci Rep
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Generation of an iPSC line (HUSTi002-A) from fibroblasts of a patient with Sertoli cell-only syndrome carrying c.731_732delAT in PIWIL2 gene. Wang X et al., 2020 Jan, Stem Cell Res
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ERK Activation Modulates Cancer Stemness and Motility of a Novel Mouse Oral Squamous Cell Carcinoma Cell Line. Chen YL et al., 2019 Dec 24, Cancers (Basel)
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In silico identification of thiostrepton as an inhibitor of cancer stem cell growth and an enhancer for chemotherapy in non-small-cell lung cancer. Huang TH et al., 2019 Dec, J Cell Mol Med
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Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets. Chien CH et al., 2019 Oct 19, J Biomed Sci
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Oct4 antibody [GT486]

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Overview

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