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WB analysis of HeLa, MEF cells, and rat brain tissue lysate using GTX48589 OPA1 antibody. Dilution : 1 microg/ml
WB analysis of HeLa, MEF cells, and rat brain tissue lysate using GTX48589 OPA1 antibody. Dilution : 1 microg/ml
WB analysis of HeLa, MEF cells, and rat brain tissue lysate using GTX48589 OPA1 antibody. Dilution : 1 microg/ml

OPA1 antibody

GTX48589
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityChicken, Human, Mouse, Porcine, Primate, Rat, Zebra Fish
TargetOPA1
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Overview

  • Supplier
    GeneTex
  • Product Name
    OPA1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 2 microg/ml. IHC-P: 2.5 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4976
  • Target name
    OPA1
  • Target description
    OPA1 mitochondrial dynamin like GTPase
  • Target synonyms
    BERHS, MGM1, MTDPS14, NPG, NTG, largeG, dynamin-like GTPase OPA1, mitochondrial, dynamin-like 120 kDa protein, mitochondrial, dynamin-like guanosine triphosphatase, mitochondrial dynamin-like GTPase, optic atrophy 1 (autosomal dominant), optic atrophy protein 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO60313
  • Protein Name
    Dynamin-like GTPase OPA1, mitochondrial
  • Scientific Description
    This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Reactivity
    Chicken, Human, Mouse, Porcine, Primate, Rat, Zebra Fish
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Chung KP, Hsu CL, Fan LC, et al. Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. Nat Commun. 2019,10(1):3390. doi: 10.1038/s41467-019-11327-1
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  • Pabón MA, Patino E, Bhatia D, et al. Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease. JCI Insight. 2018,3(18):pii: 99592. doi: 10.1172/jci.insight.99592.
    Read this paper
  • Hsu JY, Jhang YL, Cheng PH, et al. The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models. Front Mol Neurosci. 2017,10:196. doi: 10.3389/fnmol.2017.00196
    Read this paper
  • Barbier V, Lang D, Valois S, et al. Dengue virus induces mitochondrial elongation through impairment of Drp1-triggered mitochondrial fission. Virology. 2017,500:149-160. doi: 10.1016/j.virol.2016.10.022
    Read this paper
  • Cheng CT, Kuo CY, Ouyang C, et al. Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells. Cancer Res. 2016,76(17):5006-18. doi: 10.1158/0008-5472.CAN-15-2921
    Read this paper
  • Yu CY, Liang JJ, Li JK, et al. Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. PLoS Pathog. 2015,11(12):e1005350. doi: 10.1371/journal.ppat.1005350
    Read this paper
  • Ballweg K, Mutze K, Königshoff M, et al. Cigarette smoke extract affects mitochondrial function in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2014,307(11):L895-907. doi: 10.1152/ajplung.00180.2014
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  • Yang JY, Deng W, Chen Y, et al. Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium. J Mol Cell Cardiol. 2013,59:167-75. doi: 10.1016/j.yjmcc.2013.02.016
    Read this paper