WB analysis of HeLa, MEF cells, and rat brain tissue lysate using GTX48589 OPA1 antibody. Dilution : 1 microg/ml
WB analysis of HeLa, MEF cells, and rat brain tissue lysate using GTX48589 OPA1 antibody. Dilution : 1 microg/ml
OPA1 antibody
GTX48589
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetOPA1
Overview
- SupplierGeneTex
- Product NameOPA1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 2 microg/ml. IHC-P: 2.5 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID4976
- Target nameOPA1
- Target descriptionOPA1 mitochondrial dynamin like GTPase
- Target synonymsBERHS, MGM1, MTDPS14, NPG, NTG, largeG, dynamin-like GTPase OPA1, mitochondrial, dynamin-like 120 kDa protein, mitochondrial, dynamin-like guanosine triphosphatase, mitochondrial dynamin-like GTPase, optic atrophy 1 (autosomal dominant), optic atrophy protein 1
- HostRabbit
- IsotypeIgG
- Protein IDO60313
- Protein NameDynamin-like GTPase OPA1, mitochondrial
- Scientific DescriptionThis gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Chung KP, Hsu CL, Fan LC, et al. Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. Nat Commun. 2019,10(1):3390. doi: 10.1038/s41467-019-11327-1Read this paper
- Pabón MA, Patino E, Bhatia D, et al. Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease. JCI Insight. 2018,3(18):pii: 99592. doi: 10.1172/jci.insight.99592.Read this paper
- Hsu JY, Jhang YL, Cheng PH, et al. The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models. Front Mol Neurosci. 2017,10:196. doi: 10.3389/fnmol.2017.00196Read this paper
- Barbier V, Lang D, Valois S, et al. Dengue virus induces mitochondrial elongation through impairment of Drp1-triggered mitochondrial fission. Virology. 2017,500:149-160. doi: 10.1016/j.virol.2016.10.022Read this paper
- Cheng CT, Kuo CY, Ouyang C, et al. Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells. Cancer Res. 2016,76(17):5006-18. doi: 10.1158/0008-5472.CAN-15-2921Read this paper
- Yu CY, Liang JJ, Li JK, et al. Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. PLoS Pathog. 2015,11(12):e1005350. doi: 10.1371/journal.ppat.1005350Read this paper
- Ballweg K, Mutze K, Königshoff M, et al. Cigarette smoke extract affects mitochondrial function in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2014,307(11):L895-907. doi: 10.1152/ajplung.00180.2014Read this paper
- Yang JY, Deng W, Chen Y, et al. Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium. J Mol Cell Cardiol. 2013,59:167-75. doi: 10.1016/j.yjmcc.2013.02.016Read this paper
Datasheet
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