OPA1 antibody

Name: OPA1 antibody
SKU: GTX48589_G10
Availability: BackOrder

GTX48589

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityChicken, Human, Mouse, Porcine, Primate, Rat, Zebra Fish

TargetOPA1

Overview

Supplier
GeneTex
Product Name
OPA1 antibody
Delivery Days Customer
9
Application Supplier Note
WB: 2 microg/ml. IHC-P: 2.5 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID4976
Target name
OPA1
Target description
OPA1 mitochondrial dynamin like GTPase
Target synonyms
BERHS, MGM1, MTDPS14, NPG, NTG, largeG, dynamin-like GTPase OPA1, mitochondrial, dynamin-like 120 kDa protein, mitochondrial, dynamin-like guanosine triphosphatase, mitochondrial dynamin-like GTPase, optic atrophy 1 (autosomal dominant), optic atrophy protein 1
Host
Rabbit
Isotype
IgG
Protein IDO60313
Protein Name
Dynamin-like GTPase OPA1, mitochondrial
Scientific Description
This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Reactivity
Chicken, Human, Mouse, Porcine, Primate, Rat, Zebra Fish
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
41116161

Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. Chung KP et al., 2019 Jul 29, Nat Commun
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Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease. Pabon MA et al., 2018 Sep 20, JCI Insight
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The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models. Hsu JY et al., 2017, Front Mol Neurosci
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Dengue virus induces mitochondrial elongation through impairment of Drp1-triggered mitochondrial fission. Barbier V et al., 2017 Jan, Virology
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Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells. Cheng CT et al., 2016 Sep 1, Cancer Res
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Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. Yu CY et al., 2015 Dec, PLoS Pathog
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Cigarette smoke extract affects mitochondrial function in alveolar epithelial cells. Ballweg K et al., 2014 Dec 1, Am J Physiol Lung Cell Mol Physiol
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Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium. Yang JY et al., 2013 Jun, J Mol Cell Cardiol
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