p27 Kip1 antibody
GTX100446
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetCDKN1B
Overview
- SupplierGeneTex
- Product Namep27 Kip1 antibody
- Delivery Days Customer9
- Antibody SpecificityIP/MS validation was supported by references (PMID:30377371)
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IHC-Fr: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.08 mg/ml
- ConjugateUnconjugated
- Gene ID1027
- Target nameCDKN1B
- Target descriptioncyclin dependent kinase inhibitor 1B
- Target synonymsCDKN4; cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); KIP1; MEN1B; MEN4; P27KIP1
- HostRabbit
- IsotypeIgG
- Protein IDP46527
- Protein NameCyclin-dependent kinase inhibitor 1B
- Scientific DescriptionThis gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Tumor targeting and therapeutic assessments of RNA nanoparticles carrying alpha9-nAChR aptamer and anti-miR-21 in triple-negative breast cancers.Read more
- CRISPR-mediated knockout of VEGFR2/KDR inhibits cell growth in a squamous thyroid cancer cell line. Tsai ML et al., 2022 May, FEBS Open BioRead more
- Upregulation of miR-34a-5p, miR-20a-3p and miR-29a-3p by Onconase in A375 Melanoma Cells Correlates with the Downregulation of Specific Onco-Proteins. De Tomi E et al., 2022 Jan 31, Int J Mol SciRead more
- Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo. Mao BH et al., 2022 Jan 14, Part Fibre ToxicolRead more
- 9-O-Terpenyl-Substituted Berberrubine Derivatives Suppress Tumor Migration and Increase Anti-Human Non-Small-Cell Lung Cancer Activity. Chang JM et al., 2021 Sep 13, Int J Mol SciRead more
- Decreased proliferation of aged rat beta cells corresponds with enhanced expression of the cell cycle inhibitor p27(KIP1).Read more
- Effect of butyrate, a bacterial by-product, on the viability and ICAM-1 expression/production of human vascular endothelial cells: Role in infectious pulpal/periapical diseases. Chang MC et al., 2022 Jan, Int Endod JRead more
- Platelet-Derived Growth Factor Receptor-alpha Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo. Lin CL et al., 2021 Sep 1, Biomol Ther (Seoul)Read more
- Progesterone receptor membrane component 1 is involved in oral cancer cell metastasis. Huang HY et al., 2020 Sep, J Cell Mol MedRead more
- FAK Inhibition Induces Glioblastoma Cell Senescence-Like State through p62 and p27. Alza L et al., 2020 Apr 27, Cancers (Basel)Read more