p27 Kip1 antibody
GTX100446
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetCDKN1B
Overview
- SupplierGeneTex
- Product Namep27 Kip1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IHC-Fr: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.08 mg/ml
- ConjugateUnconjugated
- Gene ID1027
- Target nameCDKN1B
- Target descriptioncyclin dependent kinase inhibitor 1B
- Target synonymsCDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- HostRabbit
- IsotypeIgG
- Protein IDP46527
- Protein NameCyclin-dependent kinase inhibitor 1B
- Scientific DescriptionThis gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Liao YC, Cheng TC, Tu SH, et al. Tumor targeting and therapeutic assessments of RNA nanoparticles carrying α9-nAChR aptamer and anti-miR-21 in triple-negative breast cancers. Mol Ther Nucleic Acids. 2023,33:351-366. doi: 10.1016/j.omtn.2023.07.013Read this paper
- Tsai ML, Lee CH, Huang LC, et al. CRISPR-mediated knockout of VEGFR2/KDR inhibits cell growth in a squamous thyroid cancer cell line. FEBS Open Bio. 2022,12(5):993-1005. doi: 10.1002/2211-5463.13399Read this paper
- De Tomi E, Campagnari R, Orlandi E, et al. Upregulation of miR-34a-5p, miR-20a-3p and miR-29a-3p by Onconase in A375 Melanoma Cells Correlates with the Downregulation of Specific Onco-Proteins. Int J Mol Sci. 2022,23(3). doi: 10.3390/ijms23031647Read this paper
- Mao BH, Luo YK, Wang BJ, et al. Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo. Part Fibre Toxicol. 2022,19(1):6. doi: 10.1186/s12989-022-00447-0Read this paper
- Chang JM, Wu JY, Chen SH, et al. 9-O-Terpenyl-Substituted Berberrubine Derivatives Suppress Tumor Migration and Increase Anti-Human Non-Small-Cell Lung Cancer Activity. Int J Mol Sci. 2021,22(18). doi: 10.3390/ijms22189864Read this paper
- Aitken TJ, Crabtree JE, Jensen DM, et al. Decreased proliferation of aged rat beta cells corresponds with enhanced expression of the cell cycle inhibitor p27(KIP1). Biol Cell. 2021,113(12):507-521. doi: 10.1111/boc.202100035Read this paper
- Chang MC, Wang TM, Chien HH, et al. Effect of butyrate, a bacterial by-product, on the viability and ICAM-1 expression/production of human vascular endothelial cells: Role in infectious pulpal/periapical diseases. Int Endod J. 2022,55(1):38-53. doi: 10.1111/iej.13614Read this paper
- Lin CL, Tsai ML, Chen YH, et al. Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo. Biomol Ther (Seoul). 2021,29(5):551-561. doi: 10.4062/biomolther.2020.205Read this paper
- Huang HY, Chou HC, Law CH, et al. Progesterone receptor membrane component 1 is involved in oral cancer cell metastasis. J Cell Mol Med. 2020,24(17):9737-9751. doi: 10.1111/jcmm.15535Read this paper
- Alza L, Nàger M, Visa A, et al. FAK Inhibition Induces Glioblastoma Cell Senescence-Like State through p62 and p27. Cancers (Basel). 2020,12(5). doi: 10.3390/cancers12051086Read this paper
Datasheet
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