IHC-P analysis of human brain tissue using GTX24822 p38 MAPK (phospho Thr180/Tyr182) antibody. Right : Primary antibody Left : Negative control without primary antibody Antigen retrieval : 10mM sodium citrate (pH 6.0), microwaved for 8-15 min Dilution : 1:100
IHC-P analysis of human brain tissue using GTX24822 p38 MAPK (phospho Thr180/Tyr182) antibody. Right : Primary antibody Left : Negative control without primary antibody Antigen retrieval : 10mM sodium citrate (pH 6.0), microwaved for 8-15 min Dilution : 1:100
p38 MAPK (phospho Thr180/Tyr182) antibody
GTX24822
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMAPK14
Overview
- SupplierGeneTex
- Product Namep38 MAPK (phospho Thr180/Tyr182) antibody - Orthogonal Validated
- Delivery Days Customer9
- Antibody SpecificityReacts with p38 alpha, beta and gamma.
- Application Supplier NoteWB: 1:500-1:2000. ICC/IF: 1 microg/ml. IHC-P: 1:10-1:100. FACS: 3-5 microg/106 cells. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID1432
- Target nameMAPK14
- Target descriptionmitogen-activated protein kinase 14
- Target synonymsCSAID-binding protein; CSBP; CSBP1; CSBP2; CSPB1; cytokine suppressive anti-inflammatory drug binding protein; EXIP; MAP kinase 14; MAP kinase Mxi2; MAP kinase p38 alpha; MAX-interacting protein 2; mitogen-activated protein kinase 14; mitogen-activated protein kinase p38 alpha; Mxi2; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38ALPHA; p38alpha Exip; PRKM14; PRKM15; RK; SAPK2A; stress-activated protein kinase 2A
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Protein IDQ16539
- Protein NameMitogen-activated protein kinase 14
- Scientific DescriptionThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
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- Long-term Therapeutic Effects of Extracorporeal Shock Wave-Assisted Melatonin Therapy on Mononeuropathic Pain in Rats. Yang CH et al., 2019 Apr, Neurochem ResRead more
- Leptin induces matrix metalloproteinase 7 expression to promote ovarian cancer cell invasion by activating ERK and JNK pathways. Ghasemi A et al., 2018 Feb, J Cell BiochemRead more
- The Anti-Inflammatory Effects and Mechanisms of Eupafolin in Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Macrophages. Chen CC et al., 2016, PLoS OneRead more
- Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy. Lee YR et al., 2012 Jan 27, J Biomed SciRead more