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Western Blot analysis of HepG2 cells using p53 Polyclonal Antibody at dilution of 1:1000.
Western Blot analysis of HepG2 cells using p53 Polyclonal Antibody at dilution of 1:1000.
Western Blot analysis of HepG2 cells using p53 Polyclonal Antibody at dilution of 1:1000.

p53 Polyclonal Antibody

Research Use Only
E-AB-32469
Elabscience
Product group Antibodies
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More than 130 suppliers
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Overview

  • Supplier
    Elabscience
  • Product Name
    p53 Polyclonal Antibody
  • Delivery Days Customer
    12
  • Applications Supplier
    WB,IHC,IF,ELISA
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Scientific Description
    Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
  • UNSPSC
    12352203