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ProductsBack/PARP antibody [10H]
Immunohistochemistry of livers treated with diethylnitrosamine (200 mg/kg) andstained with GTX14459 diluted 1/100.After treatment livers were removed and rapidly processed 10 hr later, at peak polymer induction.
Immunohistochemistry of livers treated with diethylnitrosamine (200 mg/kg) andstained with GTX14459 diluted 1/100.After treatment livers were removed and rapidly processed 10 hr later, at peak polymer induction.
Immunohistochemistry of livers treated with diethylnitrosamine (200 mg/kg) andstained with GTX14459 diluted 1/100.After treatment livers were removed and rapidly processed 10 hr later, at peak polymer induction.

PARP antibody [10H]

GTX14459
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
DownloadDatasheet
Product group Antibodies
TargetPARP1
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Overview

  • Supplier
    GeneTex
  • Product Name
    PARP antibody [10H]
  • Delivery Days Customer
    9
  • Application Supplier Note
    ELISA: Use at an assay dependent dilution. IHC-Fr: Use at a concentration of 5 - 20 microg/ml. WB: Use at a concentration of 2 microg/ml, if using ECL or 10 microg/ml, if using colorimetric methods. Optimal dilutions/concentrations should be determined by the end user.
  • Applications
    ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    10H
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID142
  • Target name
    PARP1
  • Target description
    poly(ADP-ribose) polymerase 1
  • Target synonyms
    ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); ADPRT; ADPRT 1; ADPRT1; ARTD1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; pADPRT-1; PARP; PARP-1; poly (ADP-ribose) polymerase family, member 1; poly [ADP-ribose] polymerase 1; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; poly[ADP-ribose] synthase 1; PPOL; protein poly-ADP-ribosyltransferase PARP1
  • Host
    Mouse
  • Isotype
    IgG3
  • Protein IDP09874
  • Protein Name
    Poly [ADP-ribose] polymerase 1
  • Scientific Description
    This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation. Cesaire M et al., 2019 Aug, J Bone Oncol
    Read more
  • Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells. Gottipati P et al., 2010 Jul 1, Cancer Res
    Read more

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