IHC-P analysis of human tonsil tissue using GTX20256 PD1 antibody [NAT105].
IHC-P analysis of human tonsil tissue using GTX20256 PD1 antibody [NAT105].
PD1 antibody [NAT105]
GTX20256
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetPDCD1
Overview
- SupplierGeneTex
- Product NamePD1 antibody [NAT105]
- Delivery Days Customer9
- Application Supplier NoteIHC-P: 1:25-100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDNAT105
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID5133
- Target namePDCD1
- Target descriptionprogrammed cell death 1
- Target synonymsCD279; hPD-1; hPD-l; hSLE1; PD1; PD-1; programmed cell death 1 protein; programmed cell death protein 1; protein PD-1; SLEB2; systemic lupus erythematosus susceptibility 2
- HostMouse
- IsotypeIgG1
- Protein IDQ15116
- Protein NameProgrammed cell death protein 1
- Scientific DescriptionThis gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas. Zhang S et al., 2020 Feb 17, BMC CancerRead more
- Assessing PDL-1 and PD-1 in Non-Small Cell Lung Cancer: A Novel Immunoscore Approach. Paulsen EE et al., 2017 Mar, Clin Lung CancerRead more
- Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer. Kaewkangsadan V et al., 2016, J Immunol ResRead more
- Independent association of PD-L1 expression with noninactivated VHL clear cell renal cell carcinoma-A finding with therapeutic potential. Kammerer-Jacquet SF et al., 2017 Jan 1, Int J CancerRead more
- Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Li CW et al., 2016 Aug 30, Nat CommunRead more
- T cell Bim levels reflect responses to anti-PD-1 cancer therapy. Dronca RS et al., 2016 May 5, JCI InsightRead more
- Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer. Bastman JJ et al., 2016 Jul, J Clin Endocrinol MetabRead more
- Differential induction of PD-1/PD-L1 in Neuroimmune cells by drug of abuse. Mishra V et al., 2015, Int J Physiol Pathophysiol PharmacolRead more
- Lichenoid dermatitis in three patients with metastatic melanoma treated with anti-PD-1 therapy. Joseph RW et al., 2015 Jan, Cancer Immunol ResRead more
- The histopathology of labial salivary glands in primary Sjoegrens syndrome: focusing on follicular helper T cells in the inflammatory infiltrates. Szabo K et al., 2014, Mediators InflammRead more