PE/Cyanine7 Anti-Mouse CD122 Antibody

Reddot Biotech

PE/Cyanine7 Anti-Mouse CD122 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

5H4

Double Conjugated

Il2rb

interleukin 2 receptor, beta chain

CD122; high affinity IL-2 receptor subunit beta; IL-15 receptor beta chain; IL15R; IL-15R; IL15Rbeta; IL-15Rbeta; IL-2 receptor beta chain; IL-2 receptor subunit beta; IL-2/15 receptor-beta; Il-2/15Rbeta; Il-2R; IL-2R subunit beta; IL-2RB; Il-2Rbeta; interleukin-2 receptor subunit beta; p70; p70-75

Rat

IgG2a

CD122 is a 70-75 kD IL-2 receptor beta chain also known as IL-2Rbeta, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rbeta chain can combine with either the common Oe≥ subunit (Oe≥c, CD132) alone or with the Oe≥c subunit and the IL-2ROe+/- subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

2°C to 8°C

12352203