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Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with PFKFB4 antibody [HL3254] (GTX640901) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.
Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with PFKFB4 antibody [HL3254] (GTX640901) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.
Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with PFKFB4 antibody [HL3254] (GTX640901) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.

PFKFB4 antibody [HL3254]

GTX640901
GeneTex
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Rat
TargetPFKFB4
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Overview

  • Supplier
    GeneTex
  • Product Name
    PFKFB4 antibody [HL3254]
  • Delivery Days Customer
    7
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    HL3254
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5210
  • Target name
    PFKFB4
  • Target description
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
  • Target synonyms
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6PF-2-K/Fru-2,6-P2ase 4, 6PF-2-K/Fru-2,6-P2ase testis-type isozyme, PFK/FBPase 4, bifunctional enzyme with kinase and biphosphatase activities
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ16877
  • Protein Name
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
  • Scientific Description
    The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
  • Reactivity
    Human, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    41116161

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