Phospho-STAT2 (Tyr690) Antibody

Cusabio

Phospho-STAT2 (Tyr690) Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

STAT2

signal transducer and activator of transcription 2

IMD44; interferon alpha induced transcriptional activator; ISGF-3; P113; PTORCH3; signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT113

Rabbit

IgG

Signal transducer and activator of transcription 2

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) hasbeen shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. Fu X.Y,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7840-7843(1992) Yan R,et al. Nucleic Acids Res. 23:459-463(1995) Fu X.Y.Cell 70:323-335(1992) Sugiyama T,et al.FEBS Lett. 381:191-194(1996)

Human

-20°C or -80°C

12352203