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ProductsBack/PIM2 antibody [8G10] - Overexpression Validated
IHC-P analysis of breast adenocarcinoma tissue using GTX83890 PIM2 antibody [8G10]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50
IHC-P analysis of breast adenocarcinoma tissue using GTX83890 PIM2 antibody [8G10]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50
IHC-P analysis of breast adenocarcinoma tissue using GTX83890 PIM2 antibody [8G10]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50

PIM2 antibody [8G10] - Overexpression Validated

Research Use Only
GTX83890
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetPIM2
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Overview

  • Supplier
    GeneTex
  • Product Name
    PIM2 antibody [8G10] - Overexpression Validated
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    8G10
  • Concentration
    0.81 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID11040
  • Target name
    PIM2
  • Target description
    Pim-2 proto-oncogene, serine/threonine kinase
  • Target synonyms
    pim-2 oncogene; pim-2h; proto-oncogene Pim-2 (serine threonine kinase); serine/threonine-protein kinase pim-2
  • Host
    Mouse
  • Isotype
    IgG2b
  • Scientific Description
    Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappaB kinase/NF-kappaB cascade - this process requires phosphorylation of MAP3K8/COT. Prevents apoptosis induced by growth factor withdrawal via inhibition of caspase-3 activation, and via phosphorylation of pro-apoptotic proteins. Inhibits BAD-induced cell death via phosphorylation of BAD. PIM2-mediated cell survival is glucose-dependent but independent of several AKT regulators such as PI3K, HSP-90 and TOR, indicating that PIM2 and PI3K/AKT/TOR function via distinct pathways. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203