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PPAR alpha antibody

GTX101098
GeneTex
ApplicationsImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPPARA
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Overview

  • Supplier
    GeneTex
  • Product Name
    PPAR alpha antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.04 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5465
  • Target name
    PPARA
  • Target description
    peroxisome proliferator activated receptor alpha
  • Target synonyms
    hPPAR; NR1C1; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; peroxisome proliferator-activated receptor alpha; PPAR; PPARalpha; PPAR-alpha
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ07869
  • Protein Name
    Peroxisome proliferator-activated receptor alpha
  • Scientific Description
    Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions.
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  • Berberine Reduces Lipid Accumulation in Obesity via Mediating Transcriptional Function of PPARdelta.
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  • Selective activation of PPARalpha maintains thermogenic capacity of beige adipocytes.
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  • Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.
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  • Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria. Toda T et al., 2022 May 12, Commun Biol
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  • Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE-/- Mice. Lin CH et al., 2021 Nov 9, Nutrients
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  • Alleviative Effect of Ruellia tuberosa L. on Insulin Resistance and Abnormal Lipid Accumulation in TNF-alpha-Treated FL83B Mouse Hepatocytes. Chen HJ et al., 2021, Evid Based Complement Alternat Med
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  • Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-Ay mice. Igarashi Y et al., 2021 Aug, Biomed Pharmacother
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  • Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARalpha signaling pathway. Dai J et al., 2021 Jan 26, Elife
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  • Upregulation of peroxisome proliferator-activated receptor-alpha and the lipid metabolism pathway promotes carcinogenesis of ampullary cancer. Wang CY et al., 2021, Int J Med Sci
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