PPARA Polyclonal Antibody
RD70035A
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetPPARA
Overview
- SupplierReddot Biotech
- Product NamePPARA Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration2 mg/ml
- ConjugateUnconjugated
- Gene ID5465
- Target namePPARA
- Target descriptionperoxisome proliferator activated receptor alpha
- Target synonymshPPAR; NR1C1; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; peroxisome proliferator-activated receptor alpha; PPAR; PPARalpha; PPAR-alpha
- HostRabbit
- IsotypeIgG
- Scientific DescriptionPeroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid beta-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-kappaB, causing inhibition of its signaling pathway or reducing the activated levels of NF-kappaB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203