Bio-Connect

PPARA Polyclonal Antibody

RD70035A
Reddot Biotech
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetPPARA
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    PPARA Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    2 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5465
  • Target name
    PPARA
  • Target description
    peroxisome proliferator activated receptor alpha
  • Target synonyms
    hPPAR; NR1C1; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; peroxisome proliferator-activated receptor alpha; PPAR; PPARalpha; PPAR-alpha
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid beta-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-kappaB, causing inhibition of its signaling pathway or reducing the activated levels of NF-kappaB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203