ProductsBack/PPT1 antibody [N1C3]

PPT1 antibody [N1C3]

Name: PPT1 antibody [N1C3]
SKU: GTX110677_G10
Availability: BackOrder

GTX110677

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetPPT1

Overview

Supplier
GeneTex
Product Name
PPT1 antibody [N1C3]
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID5538
Target name
PPT1
Target description
palmitoyl-protein thioesterase 1
Target synonyms
CLN1, INCL, PPT, palmitoyl-protein thioesterase 1, ceroid-palmitoyl-palmitoyl-protein thioesterase 1, palmitoyl-protein hydrolase 1
Host
Rabbit
Isotype
IgG
Protein IDP50897
Protein Name
Palmitoyl-protein thioesterase 1
Scientific Description
The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Gorenberg EL, Massaro Tieze S, Yücel B, et al. Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function. PLoS Biol. 2022,20(3):e3001590. doi: 10.1371/journal.pbio.3001590
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You BJ, Hour MJ, Chen LY, et al. Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase. Sci Rep. 2019,9(1):3306. doi: 10.1038/s41598-019-39778-y
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You BJ, Chen LY, Hsu PH, et al. Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells. Chem Res Toxicol. 2019,32(2):255-264. doi: 10.1021/acs.chemrestox.8b00269
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Henderson MX, Wirak GS, Zhang YQ, et al. Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Acta Neuropathol. 2016,131(4):621-37. doi: 10.1007/s00401-015-1512-2
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