PPT1 antibody [N1C3]
GTX110677
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetPPT1
Overview
- SupplierGeneTex
- Product NamePPT1 antibody [N1C3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID5538
- Target namePPT1
- Target descriptionpalmitoyl-protein thioesterase 1
- Target synonymsceroid-palmitoyl-palmitoyl-protein thioesterase 1; CLN1; INCL; palmitoyl-protein hydrolase 1; palmitoyl-protein thioesterase 1; PPT
- HostRabbit
- IsotypeIgG
- Protein IDP50897
- Protein NamePalmitoyl-protein thioesterase 1
- Scientific DescriptionThe protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function. Gorenberg EL et al., 2022 Mar, PLoS BiolRead more
- Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase. You BJ et al., 2019 Mar 1, Sci RepRead more
- Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells. You BJ et al., 2019 Feb 18, Chem Res ToxicolRead more
- Neuronal ceroid lipofuscinosis with DNAJC5/CSPalpha mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Henderson MX et al., 2016 Apr, Acta NeuropatholRead more