PXR antibody, Internal

GeneTex

PXR antibody, Internal

7

This antibody is expected to recognize all reported isoforms (NP_071285.1; NP_148934.1; NP_003880.3).

WB: 1-3microg/ml. IHC-P: 3.75microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

NR1I2

nuclear receptor subfamily 1 group I member 2

BXR; nuclear receptor subfamily 1 group I member 2; ONR1; orphan nuclear receptor PAR1; orphan nuclear receptor PXR; PAR; PAR1; PAR2; PARq; pregnane X nuclear receptor variant 2; pregnane X receptor; PRR; PXR; SAR; steroid and xenobiotic receptor; SXR

Goat

IgG

Nuclear receptor subfamily 1 group I member 2

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203