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Renin Receptor antibody [N3C3]

GTX114169
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetATP6AP2
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Overview

  • Supplier
    GeneTex
  • Product Name
    Renin Receptor antibody [N3C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.38 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10159
  • Target name
    ATP6AP2
  • Target description
    ATPase H+ transporting accessory protein 2
  • Target synonyms
    APT6M8-9; ATP6IP2; ATP6M8-9; ATPase H(+)-transporting lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9; ATPase, H+ transporting, lysosomal accessory protein 2; ATPase, H+ transporting, lysosomal interacting protein 2; CDG2R; ELDF10; embryonic liver differentiation factor 10; ER-localized type I transmembrane adapter; ER-localized type I transmembrane adaptor; HT028; M8-9; MRXE; MRXSH; MSTP009; N14F; prorenin receptor; PRR; renin receptor; renin/prorenin receptor; RENR; vacuolar ATP synthase membrane sector-associated protein M8-9; vacuolar proton ATP synthase membrane sector associated protein M8-9; V-ATPase M8.9 subunit; XMRE; XPDS
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO75787
  • Protein Name
    Renin receptor
  • Scientific Description
    This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Cleavage of the V-ATPase associated prorenin receptor is mediated by PACE4 and is essential for growth of prostate cancer cells.
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  • Elevated V-ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer. Mohammad AH et al., 2020 Oct, Mol Cancer Res
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  • V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss. Mohammad AH et al., 2019 Aug 13, Oncotarget
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  • Elemene inhibits osteosarcoma growth by suppressing the renin-angiotensin system signaling pathway. Ding L et al., 2018 Jan, Mol Med Rep
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  • Prorenin receptor acts as a potential molecular target for pancreatic ductal adenocarcinoma diagnosis. Arundhathi A et al., 2016 Aug 23, Oncotarget
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  • Site-1 protease is required for the generation of soluble (pro)renin receptor. Nakagawa T et al., 2017 Apr 1, J Biochem
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  • Participation of the extracellular domain in (pro)renin receptor dimerization. Suzuki-Nakagawa C et al., 2014 Feb 21, Biochem Biophys Res Commun
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