More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/RPA32 antibody - Orthogonal Validated

RPA32 antibody - Orthogonal Validated

Research Use Only
GTX70258
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetRPA2
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    GeneTex
  • Product Name
    RPA32 antibody - Orthogonal Validated
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID6118
  • Target name
    RPA2
  • Target description
    replication protein A2
  • Target synonyms
    REPA2; replication factor A protein 2; replication protein A 32 kDa subunit; replication protein A 34 kDa subunit; RF-A protein 2; RP-A p32; RP-A p34; RPA32
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair. Chen CC et al., 2018 Sep 10, Cancers (Basel)
    Read more
  • The ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice. Adeyemi RO et al., 2014 Sep 1, J Virol
    Read more
  • Human RECQL1 participates in telomere maintenance. Popuri V et al., 2014 May, Nucleic Acids Res
    Read more
  • Stepwise activation of the ATR signaling pathway upon increasing replication stress impacts fragile site integrity. Koundrioukoff S et al., 2013, PLoS Genet
    Read more
  • Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication. Adeyemi RO et al., 2010 Oct 7, PLoS Pathog
    Read more
  • Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination. Draskovic I et al., 2009 Sep 15, Proc Natl Acad Sci U S A
    Read more
  • Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. Nichols GJ et al., 2009 Jun, J Virol
    Read more