Sheep anti Human chx 10 (Visual system homeobox 2) (CT)
X1179P
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityChicken, Human, Mouse, Rat
TargetVSX2
Overview
- SupplierNordic-MUbio
- Product NameSheep anti Human chx 10 (Visual system homeobox 2) (CT)
- Delivery Days Customer7
- Application Supplier NoteDetects Chx10 by Western blot at 0.5 to 1 microg/ml. Detects a 46 kDa band in mouse and rat retinal tissue lysates. Optimal concentration should be evaluated by serial dilutions. Suitable for use against recombinant proteins conjugated to OVA, GST, His tags and other.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- Applications SupplierWestern Blotting;Immunohistochemistry (frozen)
- Category SupplierPrimary antibodies
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID338917
- Target nameVSX2
- Target descriptionvisual system homeobox 2
- Target synonymsceh-10 homeo domain containing homolog; ceh-10 homeodomain-containing homolog; CHX10; homeobox protein CHX10; HOX10; MCOP2; MCOPCB3; RET1; visual system homeobox 2
- HostSheep
- IsotypeIgG
- Protein IDP58304
- Protein NameVisual system homeobox 2
- Scientific DescriptionCeh-10 homeodomain-containing homolog
- Shelf life instructionSee expiration date on vial
- ReactivityChicken, Human, Mouse, Rat
- Reactivity SupplierHuman;Mouse;Rat;Chicken
- UNSPSC12352203
References
- 1. Liu, I.S., et al. Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer. Neuron 1994, 13, 377-393 2. Chen, C.M. & Cepko, C.L. Expression of Chx10 and Chx10-1 in the developing chicken retina. Mech. Dev. 2000, 90, 293-297 3. Ferda Percin, E., et al. Human microphthalmia associated with mutations in the retinal homeobox gene CHX10. Nat. Genet. 2000, 25, 397-401 4. Nittner, D., et al. Synthetic lethality between Rb, p53 and Dicer or miR-17–92 in retinal progenitors suppresses retinoblastoma formation. Nature Cell Biology (2012), 14, 958-965 5. Kay, J.N., et al. Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate. Nature Neuroscience (2011), 14, 965-972 6. Eiraku, M., et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature (2011), 472, 51-56 7. Pierfelice, T.J., et al. Notch3 Activation Promotes Invasive Glioma Formation in a Tissue Site-Specific Manner. Cancer Res., 71, 1115-1125 (2011). PRODUCT SPECIFIC REFERENCES 1. Qiu, F., et al, 'A Comprehensive Negative Regulatory Program Controlled by Brn3b to Ensure Ganglion Cell Specification from Multipotential Retinal Precursors' Journal of Neuroscience (2008), 28, , 3392-3403 2. Elshatory, Y., et a, 'Islet-1 Controls the Differentiation of Retinal Bipolar and Cholinergic Amacrine Cells' Journal of Neuroscience (2007), 27, , 12707-12720 3. Osakada, F., et al, 'Wnt Signaling Promotes Regeneration in the Retina of Adult Mammals' Journal of Neuroscience (2007), 27, , 4210-4219 4. Nittner, D., et al. 'Synthetic lethality between Rb, p53 and Dicer or miR-17–92 in retinal progenitors suppresses retinoblastoma formation.' Nature Cell Biology (2012), 14, 958–965 5. Tiwari, S., et al. ‘Meckelin 3 Is Necessary for Photoreceptor Outer Segment Development in Rat Meckel Syndrome.’ PLoS One, 8, e59306 (2013) 6. Sherry, D.M., et al. ‘Differential Developmental Deficits in Retinal Function in the Absence of either Protein Tyrosine Sulfotransferase-1 or -2.’ PLoS One, 7, e39702 (2012) 7. Luo, H., et al. ‘Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors.’ Proc. Natl. Acad. Sci. USA, 109, E553-E562 (2012) 8. Haynes, T., et al. ‘Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.’ Nat. Commun. 4, 2312 (2013) 9. Wakabayashi, T., et al. ‘Prolonged Expression of Puma in Cholinergic Amacrine Cells During the Development of Rat Retina.’ J. Histochem. Cytochem., 60, 777-788 (2012) 10. Bai, L., et al. ‘Birth of Cone Bipolar Cells, but Not Rod Bipolar Cells, Is Associated with Existing RGCs.’ PLoS One, 9, e83686 (2014) 11. Nakano, T., et al. ‘Self-formation of optic cups and storable stratified neural retina from human ESCs.’ Cell Stem Cell (2012) 10, 771-785 12. Huang, L., et al. ‘Bhlhb5 is Required for the Subtype Development of Retinal Amacrine and Bipolar Cells in Mice’ Dev. Dyn. (2014), 243, 279-289