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Sheep anti Human chx 10 (Visual system homeobox 2) (CT)

Research Use Only
X1179P
Nordic-MUbio
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityChicken, Human, Mouse, Rat
TargetVSX2
Price on request
250 ug
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Nordic-MUbio
  • Product Name
    Sheep anti Human chx 10 (Visual system homeobox 2) (CT)
  • Delivery Days Customer
    7
  • Application Supplier Note
    Detects Chx10 by Western blot at 0.5 to 1 microg/ml. Detects a 46 kDa band in mouse and rat retinal tissue lysates. Optimal concentration should be evaluated by serial dilutions. Suitable for use against recombinant proteins conjugated to OVA, GST, His tags and other.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Applications Supplier
    Western Blotting;Immunohistochemistry (frozen)
  • Category Supplier
    Primary antibodies
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID338917
  • Target name
    VSX2
  • Target description
    visual system homeobox 2
  • Target synonyms
    ceh-10 homeo domain containing homolog; ceh-10 homeodomain-containing homolog; CHX10; homeobox protein CHX10; HOX10; MCOP2; MCOPCB3; RET1; visual system homeobox 2
  • Host
    Sheep
  • Isotype
    IgG
  • Protein IDP58304
  • Protein Name
    Visual system homeobox 2
  • Scientific Description
    Ceh-10 homeodomain-containing homolog
  • Shelf life instruction
    See expiration date on vial
  • Reactivity
    Chicken, Human, Mouse, Rat
  • Reactivity Supplier
    Human;Mouse;Rat;Chicken
  • UNSPSC
    12352203

References

  • 1. Liu, I.S., et al. Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer. Neuron 1994, 13, 377-393 2. Chen, C.M. & Cepko, C.L. Expression of Chx10 and Chx10-1 in the developing chicken retina. Mech. Dev. 2000, 90, 293-297 3. Ferda Percin, E., et al. Human microphthalmia associated with mutations in the retinal homeobox gene CHX10. Nat. Genet. 2000, 25, 397-401 4. Nittner, D., et al. Synthetic lethality between Rb, p53 and Dicer or miR-17–92 in retinal progenitors suppresses retinoblastoma formation. Nature Cell Biology (2012), 14, 958-965 5. Kay, J.N., et al. Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate. Nature Neuroscience (2011), 14, 965-972 6. Eiraku, M., et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature (2011), 472, 51-56 7. Pierfelice, T.J., et al. Notch3 Activation Promotes Invasive Glioma Formation in a Tissue Site-Specific Manner. Cancer Res., 71, 1115-1125 (2011). PRODUCT SPECIFIC REFERENCES 1. Qiu, F., et al, 'A Comprehensive Negative Regulatory Program Controlled by Brn3b to Ensure Ganglion Cell Specification from Multipotential Retinal Precursors' Journal of Neuroscience (2008), 28, , 3392-3403 2. Elshatory, Y., et a, 'Islet-1 Controls the Differentiation of Retinal Bipolar and Cholinergic Amacrine Cells' Journal of Neuroscience (2007), 27, , 12707-12720 3. Osakada, F., et al, 'Wnt Signaling Promotes Regeneration in the Retina of Adult Mammals' Journal of Neuroscience (2007), 27, , 4210-4219 4. Nittner, D., et al. 'Synthetic lethality between Rb, p53 and Dicer or miR-17–92 in retinal progenitors suppresses retinoblastoma formation.' Nature Cell Biology (2012), 14, 958–965 5. Tiwari, S., et al. ‘Meckelin 3 Is Necessary for Photoreceptor Outer Segment Development in Rat Meckel Syndrome.’ PLoS One, 8, e59306 (2013) 6. Sherry, D.M., et al. ‘Differential Developmental Deficits in Retinal Function in the Absence of either Protein Tyrosine Sulfotransferase-1 or -2.’ PLoS One, 7, e39702 (2012) 7. Luo, H., et al. ‘Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors.’ Proc. Natl. Acad. Sci. USA, 109, E553-E562 (2012) 8. Haynes, T., et al. ‘Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.’ Nat. Commun. 4, 2312 (2013) 9. Wakabayashi, T., et al. ‘Prolonged Expression of Puma in Cholinergic Amacrine Cells During the Development of Rat Retina.’ J. Histochem. Cytochem., 60, 777-788 (2012) 10. Bai, L., et al. ‘Birth of Cone Bipolar Cells, but Not Rod Bipolar Cells, Is Associated with Existing RGCs.’ PLoS One, 9, e83686 (2014) 11. Nakano, T., et al. ‘Self-formation of optic cups and storable stratified neural retina from human ESCs.’ Cell Stem Cell (2012) 10, 771-785 12. Huang, L., et al. ‘Bhlhb5 is Required for the Subtype Development of Retinal Amacrine and Bipolar Cells in Mice’ Dev. Dyn. (2014), 243, 279-289