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ProductsBack/SMAD7 Polyclonal Antibody

Western blot analysis of extracts of various cell lines using SMAD7 Polyclonal Antibody at dilution of 1:1000.

Western blot analysis of extracts of various cell lines using SMAD7 Polyclonal Antibody at dilution of 1:1000.

Western blot analysis of extracts of various cell lines using SMAD7 Polyclonal Antibody at dilution of 1:1000.

SMAD7 Polyclonal Antibody

E-AB-63686

Product group Antibodies

Overview

Supplier
Elabscience
Product Name
SMAD7 Polyclonal Antibody
Delivery Days Customer
12
Certification
Research Use Only
Scientific Description
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
UNSPSC
12352203

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