SNAI1 (Ab-246) Antibody

Cusabio

SNAI1 (Ab-246) Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

SNAI1

snail family transcriptional repressor 1

SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1, zinc finger protein SNAI1, protein sna, protein snail homolog 1, snail 1 homolog, snail 1 zinc finger protein, snail family zinc finger 1, snail homolog 1

Rabbit

IgG

Zinc finger protein SNAI1

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. Okubo T., Cancer Res. 61:1338-1346(2001). Twigg S.R., Hum. Genet. 105:320-326(1999). Paznekas W.A., Genomics 62:42-49(1999)

Human, Mouse

-20°C or -80°C

41116161