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ProductsBack/SP1 antibody

SP1 antibody

Research Use Only
GTX110593
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetSP1
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Overview

  • Supplier
    GeneTex
  • Product Name
    SP1 antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    We do not recommend use of this product for Mouse,Rat.
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.22 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID6667
  • Target name
    SP1
  • Target description
    Sp1 transcription factor
  • Target synonyms
    specificity protein 1; transcription factor Sp1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP08047
  • Protein Name
    Transcription factor Sp1
  • Scientific Description
    Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Betulinic acid self-assembled nanoparticles for effective treatment of glioblastoma. Li Y et al., 2022 Jan 21, J Nanobiotechnology
    Read more
  • Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription. Liu L et al., 2021 Oct, Mol Cancer Ther
    Read more
  • ZEB1 Mediates Fibrosis in Corneal Endothelial Mesenchymal Transition Through SP1 and SP3. Lee J et al., 2020 Jul 1, Invest Ophthalmol Vis Sci
    Read more
  • Noggin Inhibits IL-1beta and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis. Chien SY et al., 2020 Apr 10, Cells
    Read more
  • Cellular density-dependent increases in HIF-1alpha compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region. Seira N et al., 2018 Dec, Pharmacol Res Perspect
    Read more
  • Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis. Carrasco-Torres G et al., 2017, Oxid Med Cell Longev
    Read more