STAT5A Antibody

Biorbyt

STAT5A Antibody

10

Optimal dilution of the STAT5A antibody should be determined by the researcher.

Flow Cytometry

Flow cytometry: 1-2ug/million cells FACS

Research Use Only

Monoclonal

PCRP-STAT5A-1A9

Unconjugated

STAT5A

signal transducer and activator of transcription 5A

MGF, STAT5, signal transducer and activator of transcription 5A, epididymis secretory sperm binding protein

Mouse

IgG2c

Signal transducer and activator of transcription 5A

Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4- mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.

Human

-20°C,2°C to 8°C

12352203