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Syntaxin 1a antibody

Research Use Only
GTX113559
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSTX1A
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Overview

  • Supplier
    GeneTex
  • Product Name
    Syntaxin 1a antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.28 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID6804
  • Target name
    STX1A
  • Target description
    syntaxin 1A
  • Target synonyms
    HPC-1; neuron-specific antigen HPC-1; P35-1; STX1; SYN1A; syntaxin 1A (brain); syntaxin-1A
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ16623
  • Protein Name
    Syntaxin-1A
  • Scientific Description
    Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles. Perluigi M et al., 2022 Aug, Alzheimers Dement
    Read more
  • PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids. Kuge H et al., 2020 Dec, J Lipid Res
    Read more
  • Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Tramutola A et al., 2020 Apr, Neurobiol Dis
    Read more
  • Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. Hausrat TJ et al., 2015 Apr 20, Nat Commun
    Read more
  • VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase. Baron Y et al., 2014 May 29, BMC Biol
    Read more