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Syntaxin 1a antibody

Name: Syntaxin 1a antibody
SKU: GTX113559_G10
Availability: BackOrder

GTX113559

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetSTX1A

Overview

Supplier
GeneTex
Product Name
Syntaxin 1a antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.28 mg/ml
Conjugate
Unconjugated
Gene ID6804
Target name
STX1A
Target description
syntaxin 1A
Target synonyms
HPC-1, P35-1, STX1, SYN1A, syntaxin-1A, neuron-specific antigen HPC-1, syntaxin 1A (brain)
Host
Rabbit
Isotype
IgG
Protein IDQ16623
Protein Name
Syntaxin-1A
Scientific Description
Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Lu Z, He S, Jiang J, et al. Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy. Mol Ther. 2022,30(6):2163-2175. doi: 10.1016/j.ymthe.2022.03.001
Read this paper
Perluigi M, Picca A, Montanari E, et al. Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles. Alzheimers Dement. 2022,18(8):1498-1510. doi: 10.1002/alz.12499
Read this paper
Kuge H, Miyamoto I, Yagyu KI, et al. PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids. J Lipid Res. 2020,61(12):1747-1763. doi: 10.1194/jlr.RA120001087
Read this paper
Tramutola A, Lanzillotta C, Di Domenico F, et al. Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiol Dis. 2020,137:104772. doi: 10.1016/j.nbd.2020.104772
Read this paper
Hausrat TJ, Muhia M, Gerrow K, et al. Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. Nat Commun. 2015,6:6872. doi: 10.1038/ncomms7872
Read this paper
Baron Y, Pedrioli PG, Tyagi K, et al. VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase. BMC Biol. 2014,12:39. doi: 10.1186/1741-7007-12-39
Read this paper