TDP43 antibody

Name: TDP43 antibody
SKU: GTX114210_G10
Availability: BackOrder

GTX114210

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetTARDBP

Overview

Supplier
GeneTex
Product Name
TDP43 antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.63 mg/ml
Conjugate
Unconjugated
Gene ID23435
Target name
TARDBP
Target description
TAR DNA binding protein
Target synonyms
ALS10, TDP-43, TAR DNA-binding protein 43, TAR DNA-binding protein-43
Host
Rabbit
Isotype
IgG
Protein IDQ13148
Protein Name
TAR DNA-binding protein 43
Scientific Description
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Harrell TL, Davido DJ, Bertke AS. Herpes Simplex Virus 1 (HSV-1) Infected Cell Protein 0 (ICP0) Targets of Ubiquitination during Productive Infection of Primary Adult Sensory Neurons. Int J Mol Sci. 2023,24(3). doi: 10.3390/ijms24032931
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Chu JF, Majumder P, Chatterjee B, et al. TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1. Cell Rep. 2019,29(10):3118-3133.e6. doi: 10.1016/j.celrep.2019.10.061
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Wu LS, Cheng WC, Chen CY, et al. Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons. Acta Neuropathol Commun. 2019,7(1):50. doi: 10.1186/s40478-019-0674-x
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Majumder P, Chu JF, Chatterjee B, et al. Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP. Acta Neuropathol. 2016,132(5):721-738.
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Sundararaman B, Zhan L, Blue SM, et al. Resources for the Comprehensive Discovery of Functional RNA Elements. Mol Cell. 2016,61(6):903-13. doi: 10.1016/j.molcel.2016.02.012
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Huang CC, Bose JK, Majumder P, et al. Metabolism and mis-metabolism of the neuropathological signature protein TDP-43. J Cell Sci. 2014,127(Pt 14):3024-38. doi: 10.1242/jcs.136150
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TDP43 antibody

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