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ProductsBack/Thymidylate synthase antibody [SPM453]
IHC-P analysis of human testicular carcinoma tissue using GTX35113 Thymidylate synthase antibody [SPM453].
IHC-P analysis of human testicular carcinoma tissue using GTX35113 Thymidylate synthase antibody [SPM453].
IHC-P analysis of human testicular carcinoma tissue using GTX35113 Thymidylate synthase antibody [SPM453].

Thymidylate synthase antibody [SPM453]

GTX35113
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetTYMS
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Overview

  • Supplier
    GeneTex
  • Product Name
    Thymidylate synthase antibody [SPM453]
  • Delivery Days Customer
    9
  • Application Supplier Note
    ICC/IF: 1-2microg/ml. IHC-P: 1-2microg/ml for 30 minutes at RT. FACS: 1-2microg/106 cells. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    SPM453
  • Concentration
    0.2 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7298
  • Target name
    TYMS
  • Target description
    thymidylate synthetase
  • Target synonyms
    HST422; thymidylate synthase; TMS; TS; TSase
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP04818
  • Protein Name
    Thymidylate synthase
  • Scientific Description
    Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203