Ubiquitin (human) (rec.) (untagged)

South Bay Bio

Ubiquitin (human) (rec.) (untagged)

10

Research Use Only

>99%

Liquid

Polyubiquitin-B

Protein. Human ubiquitin (aa1-76)is untagged. Source: E. coli. Formulation: Liquid. In 50mM HEPES pH 7.5. Purity: >99% (SDS-PAGE). Ubiquitin is a 76 amino acid post-translational modifier expressed throughout all tissues in eukaryotic organisms. The many roles of ubiquitin modification include proteasomal degradation, signal transduction, inflammatory response and DNA damage repair. Ubiquitin modification occurs through a pyramidal cascade of an E1 activating enzyme, E2 conjugating enzymes and an E3 ubiquitin ligase. This enzymatic cascade results in modification of a epsilon-amine of a lysine residue on a substrate protein. Substrates may either be mono- or poly-ubiquitinated by M1, K6, 11, 27, 29, 33, 48 or 63 linkages. Removal of ubiquitin from a substrate protein occurs via deconjugating enzymes, of which there are nearly 100 known enzymes with various specificities. - Ubiquitin is a 76 amino acid post-translational modifier expressed throughout all tissues in eukaryotic organisms. The many roles of ubiquitin modification include proteasomal degradation, signal transduction, inflammatory response and DNA damage repair. Ubiquitin modification occurs through a pyramidal cascade of an E1 activating enzyme, E2 conjugating enzymes and an E3 ubiquitin ligase. This enzymatic cascade results in modification of a epsilon-amine of a lysine residue on a substrate protein. Substrates may either be mono- or poly-ubiquitinated by M1, K6, 11, 27, 29, 33, 48 or 63 linkages. Removal of ubiquitin from a substrate protein occurs via deconjugating enzymes, of which there are nearly 100 known enzymes with various specificities.

-20°C,-80°C

12352202