ProductsBack/VCP antibody [N1N2], N-term

VCP antibody [N1N2], N-term

Name: VCP antibody [N1N2], N-term
SKU: GTX113030_G10
Availability: BackOrder

GTX113030

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetVCP

Overview

Supplier
GeneTex
Product Name
VCP antibody [N1N2], N-term
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.3 mg/ml
Conjugate
Unconjugated
Gene ID7415
Target name
VCP
Target description
valosin containing protein
Target synonyms
15S Mg(2+)-ATPase p97 subunit; CDC48; FTDALS6; p97; TER ATPase; TERA; transitional endoplasmic reticulum ATPase
Host
Rabbit
Isotype
IgG
Protein IDP55072
Protein Name
Transitional endoplasmic reticulum ATPase
Scientific Description
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Protein phosphatase 6 regulates trametinib sensitivity, a mitogen-activated protein kinase kinase (MEK) inhibitor, by regulating MEK1/2-ERK1/2 signaling in canine melanoma cells.
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FYCO1 Increase and Effect of Arimoclomol-Treatment in Human VCP-Pathology.
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Elevated expression of RAB3B plays important roles in chemoresistance and metastatic potential of hepatoma cells. Tsunedomi R et al., 2022 Mar 11, BMC Cancer
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Protein phosphatase 6 promotes neurite outgrowth by promoting mTORC2 activity in N2a cells. Kitamura N et al., 2021 Sep 22, J Biochem
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Pancreatic Cancer Stem-Like Cells With High Calreticulin Expression Associated With Immune Surveillance. Fujiwara Y et al., 2021 Mar 1, Pancreas
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Protein phosphatase 6 dissociates the Beclin 1/Vps34 complex and inhibits autophagy. Fujiwara N et al., 2021 May 7, Biochem Biophys Res Commun
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Cathepsin B is highly expressed in pancreatic cancer stem-like cells and is associated with patients surgical outcomes. Fujimoto T et al., 2021 Jan, Oncol Lett
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Autophagy regulates levels of tumor suppressor enzyme protein phosphatase 6. Fujiwara N et al., 2020 Dec, Cancer Sci
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Involvement of PP2A methylation in the adipogenic differentiation of bone marrow-derived mesenchymal stem cell. Ikeda S et al., 2020 Dec 26, J Biochem
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