VDAC1 Antibody, Biotin conjugated

Cusabio

VDAC1 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

VDAC1

voltage dependent anion channel 1

PORIN, VDAC-1, non-selective voltage-gated ion channel VDAC1, outer mitochondrial membrane protein porin 1, plasmalemmal porin, porin 31HL, porin 31HM, sperm binding protein 1a

Rabbit

IgG

Non-selective voltage-gated ion channel VDAC1

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).

Human

-20°C or -80°C

41116161