Immunohistochemistry of paraffin-embedded Human breast cancer tissue using XBP1 Polyclonal Antibody at dilution 1:60
Immunohistochemistry of paraffin-embedded Human breast cancer tissue using XBP1 Polyclonal Antibody at dilution 1:60
XBP1 Polyclonal Antibody
E-AB-10674
Product group Antibodies
Overview
- SupplierElabscience
- Product NameXBP1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration0.2mg/ml
- Scientific DescriptionThis gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.
- UNSPSC12352203