XPA antibody
GTX103168
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetXPA
Overview
- SupplierGeneTex
- Product NameXPA antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID7507
- Target nameXPA
- Target descriptionXPA, DNA damage recognition and repair factor
- Target synonymsDNA repair protein complementing XP-A cells; xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A; XP1; XPAC
- HostRabbit
- IsotypeIgG
- Protein IDP23025
- Protein NameDNA repair protein complementing XP-A cells
- Scientific DescriptionThis gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- APE1-dependent base excision repair of DNA photodimers in human cells.Read more
- Case Report: Identification of a Heterozygous XPA c.553C>T Mutation Causing Neurological Impairment in a Case of Xeroderma Pigmentosum Complementation Group A. Garcia-Carmona JA et al., 2021, Front GenetRead more
- DICER- and MMSET-catalyzed H4K20me2 recruits the nucleotide excision repair factor XPA to DNA damage sites. Chitale S et al., 2018 Feb 5, J Cell BiolRead more
- Transcriptional consequences of XPA disruption in human cell lines. Manandhar M et al., 2017 Sep, DNA Repair (Amst)Read more
- DICER and ZRF1 contribute to chromatin decondensation during nucleotide excision repair. Chitale S et al., 2017 Jun 2, Nucleic Acids ResRead more