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XPA antibody

GTX103168
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetXPA
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Overview

  • Supplier
    GeneTex
  • Product Name
    XPA antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7507
  • Target name
    XPA
  • Target description
    XPA, DNA damage recognition and repair factor
  • Target synonyms
    DNA repair protein complementing XP-A cells; xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A; XP1; XPAC
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP23025
  • Protein Name
    DNA repair protein complementing XP-A cells
  • Scientific Description
    This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • APE1-dependent base excision repair of DNA photodimers in human cells.
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  • Case Report: Identification of a Heterozygous XPA c.553C>T Mutation Causing Neurological Impairment in a Case of Xeroderma Pigmentosum Complementation Group A. Garcia-Carmona JA et al., 2021, Front Genet
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  • DICER- and MMSET-catalyzed H4K20me2 recruits the nucleotide excision repair factor XPA to DNA damage sites. Chitale S et al., 2018 Feb 5, J Cell Biol
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  • Transcriptional consequences of XPA disruption in human cell lines. Manandhar M et al., 2017 Sep, DNA Repair (Amst)
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  • DICER and ZRF1 contribute to chromatin decondensation during nucleotide excision repair. Chitale S et al., 2017 Jun 2, Nucleic Acids Res
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