XPA antibody

Name: XPA antibody
SKU: GTX103168_G10
Availability: BackOrder

GTX103168

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetXPA

Overview

Supplier
GeneTex
Product Name
XPA antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID7507
Target name
XPA
Target description
XPA, DNA damage recognition and repair factor
Target synonyms
XP1, XPAC, DNA repair protein complementing XP-A cells, xeroderma pigmentosum group A-complementing protein, xeroderma pigmentosum, complementation group A
Host
Rabbit
Isotype
IgG
Protein IDP23025
Protein Name
DNA repair protein complementing XP-A cells
Scientific Description
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Gautam A, Fawcett H, Burdova K, et al. APE1-dependent base excision repair of DNA photodimers in human cells. Mol Cell. 2023,83(20):3669-3678.e7. doi: 10.1016/j.molcel.2023.09.013
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García-Carmona JA, Yousefzadeh MJ, Alarcón-Soldevilla F, et al. Case Report: Identification of a Heterozygous XPA c.553C>T Mutation Causing Neurological Impairment in a Case of Xeroderma Pigmentosum Complementation Group A. Front Genet. 2021,12:717361. doi: 10.3389/fgene.2021.717361
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Chitale S, Richly H. DICER- and MMSET-catalyzed H4K20me2 recruits the nucleotide excision repair factor XPA to DNA damage sites. J Cell Biol. 2018,217(2):527-540. doi: 10.1083/jcb.201704028
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Manandhar M, Lowery MG, Boulware KS, et al. Transcriptional consequences of XPA disruption in human cell lines. DNA Repair (Amst). 2017,57:76-90. doi: 10.1016/j.dnarep.2017.06.028
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Chitale S, Richly H. DICER and ZRF1 contribute to chromatin decondensation during nucleotide excision repair. Nucleic Acids Res. 2017,45(10):5901-5912. doi: 10.1093/nar/gkx261
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