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XPC antibody

Name: XPC antibody
SKU: GTX70309_G10
Availability: BackOrder

GTX70309

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Product group Antibodies

ReactivityHuman

TargetXPC

Overview

Supplier
GeneTex
Product Name
XPC antibody
Delivery Days Customer
9
Application Supplier Note
Optimal dilutions/concentrations should be determined by the researcher.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.5 mg/ml
Conjugate
Unconjugated
Gene ID7508
Target name
XPC
Target description
XPC complex subunit, DNA damage recognition and repair factor
Target synonyms
RAD4, XP3, XPCC, p125, DNA repair protein complementing XP-C cells, mutant xeroderma pigmentosum group C, xeroderma pigmentosum, complementation group C
Host
Rabbit
Isotype
IgG
Protein IDQ01831
Protein Name
DNA repair protein complementing XP-C cells
Scientific Description
The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Reactivity
Human
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Robu M, Shah RG, Shah GM. Methods to Study Intracellular Movement and Localization of the Nucleotide Excision Repair Proteins at the DNA Lesions in Mammalian Cells. Front Cell Dev Biol. 2020,8:590242. doi: 10.3389/fcell.2020.590242
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Robu M, Shah RG, Petitclerc N, et al. Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair. Proc Natl Acad Sci U S A. 2013,110(5):1658-63. doi: 10.1073/pnas.1209507110
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Muniandy PA, Thapa D, Thazhathveetil AK, et al. Repair of laser-localized DNA interstrand cross-links in G1 phase mammalian cells. J Biol Chem. 2009,284(41):27908-27917. doi: 10.1074/jbc.M109.029025
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Liu Y, Wang Y, Rusinol AE, et al. Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A. FASEB J. 2008,22(2):603-11.
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