Bio-Connect

XPC antibody [3.26]

Research Use Only
GTX70294
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetXPC
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Overview

  • Supplier
    GeneTex
  • Product Name
    XPC antibody [3.26]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    3.26
  • Concentration
    1.15 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID7508
  • Target name
    XPC
  • Target description
    XPC complex subunit, DNA damage recognition and repair factor
  • Target synonyms
    DNA repair protein complementing XP-C cells; mutant xeroderma pigmentosum group C; p125; RAD4; xeroderma pigmentosum, complementation group C; XP3; XPCC
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ01831
  • Protein Name
    DNA repair protein complementing XP-C cells
  • Scientific Description
    The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation-Induced DNA Damage and Melanoma Susceptibility. de Semir D et al., 2021 Jun 1, Cancer Res
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  • Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption. Wang YC et al., 2020 Jul 25, Cancers (Basel)
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  • Multiple interaction nodes define the postreplication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load. Pavey S et al., 2020 Jan, Mol Oncol
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  • Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development. Sears CR et al., 2018 Mar, Am J Respir Cell Mol Biol
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  • Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer. Jia L et al., 2017 Feb 17, J Biol Chem
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  • Deficient Nucleotide Excision Repair in Squamous Cell Carcinoma Cells. Dong TK et al., 2016 Sep, Photochem Photobiol
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  • Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. Kim H et al., 2014 Apr 10, Mol Cell
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  • The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. Ramamoorthy M et al., 2013 Oct, Carcinogenesis
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  • Defective DNA repair and cell cycle arrest in cells expressing Merkel cell polyomavirus T antigen. Demetriou SK et al., 2012 Oct 15, Int J Cancer
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  • The DNA damage-binding protein XPC is a frequent target for inactivation in squamous cell carcinomas. de Feraudy S et al., 2010 Aug, Am J Pathol
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