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XPC antibody [3.26]

GTX70294
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetXPC
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Overview

  • Supplier
    GeneTex
  • Product Name
    XPC antibody [3.26]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    3.26
  • Concentration
    1.15 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7508
  • Target name
    XPC
  • Target description
    XPC complex subunit, DNA damage recognition and repair factor
  • Target synonyms
    DNA repair protein complementing XP-C cells; mutant xeroderma pigmentosum group C; p125; RAD4; xeroderma pigmentosum, complementation group C; XP3; XPCC
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ01831
  • Protein Name
    DNA repair protein complementing XP-C cells
  • Scientific Description
    The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation-Induced DNA Damage and Melanoma Susceptibility. de Semir D et al., 2021 Jun 1, Cancer Res
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  • Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption. Wang YC et al., 2020 Jul 25, Cancers (Basel)
    Read more
  • Multiple interaction nodes define the postreplication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load. Pavey S et al., 2020 Jan, Mol Oncol
    Read more
  • Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development. Sears CR et al., 2018 Mar, Am J Respir Cell Mol Biol
    Read more
  • Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer. Jia L et al., 2017 Feb 17, J Biol Chem
    Read more
  • Deficient Nucleotide Excision Repair in Squamous Cell Carcinoma Cells. Dong TK et al., 2016 Sep, Photochem Photobiol
    Read more
  • Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. Kim H et al., 2014 Apr 10, Mol Cell
    Read more
  • The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. Ramamoorthy M et al., 2013 Oct, Carcinogenesis
    Read more
  • Defective DNA repair and cell cycle arrest in cells expressing Merkel cell polyomavirus T antigen. Demetriou SK et al., 2012 Oct 15, Int J Cancer
    Read more
  • The DNA damage-binding protein XPC is a frequent target for inactivation in squamous cell carcinomas. de Feraudy S et al., 2010 Aug, Am J Pathol
    Read more

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Figure 1. Western blot analysis of XPC using anti-XPC antibody (A00473-1). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: human MCF-7whole cell lysates, Lane 2: human A549 whole cell lysates, Lane 3: rat liver tissue lysates, Lane 4: mouse lung tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-XPC antigen affinity purified polyclonal antibody (Catalog # A00473-1) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for XPC at approximately 106KD. The expected band size for XPC is at 106KD.
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