XPC antibody [3.26]
GTX70294
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetXPC
Overview
- SupplierGeneTex
- Product NameXPC antibody [3.26]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID3.26
- Concentration1.15 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID7508
- Target nameXPC
- Target descriptionXPC complex subunit, DNA damage recognition and repair factor
- Target synonymsDNA repair protein complementing XP-C cells; mutant xeroderma pigmentosum group C; p125; RAD4; xeroderma pigmentosum, complementation group C; XP3; XPCC
- HostMouse
- IsotypeIgG1
- Protein IDQ01831
- Protein NameDNA repair protein complementing XP-C cells
- Scientific DescriptionThe protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation-Induced DNA Damage and Melanoma Susceptibility. de Semir D et al., 2021 Jun 1, Cancer ResRead more
- Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption. Wang YC et al., 2020 Jul 25, Cancers (Basel)Read more
- Multiple interaction nodes define the postreplication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load. Pavey S et al., 2020 Jan, Mol OncolRead more
- Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development. Sears CR et al., 2018 Mar, Am J Respir Cell Mol BiolRead more
- Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer. Jia L et al., 2017 Feb 17, J Biol ChemRead more
- Deficient Nucleotide Excision Repair in Squamous Cell Carcinoma Cells. Dong TK et al., 2016 Sep, Photochem PhotobiolRead more
- Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. Kim H et al., 2014 Apr 10, Mol CellRead more
- The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. Ramamoorthy M et al., 2013 Oct, CarcinogenesisRead more
- Defective DNA repair and cell cycle arrest in cells expressing Merkel cell polyomavirus T antigen. Demetriou SK et al., 2012 Oct 15, Int J CancerRead more
- The DNA damage-binding protein XPC is a frequent target for inactivation in squamous cell carcinomas. de Feraudy S et al., 2010 Aug, Am J PatholRead more