Activin Receptor Type IIB antibody [6L11]

GeneTex

Activin Receptor Type IIB antibody [6L11]

9

This antibody was selected for its ability to detect human Activin RIIB. Weak cross reactivity was found to Activin RIIA

WB: 1:100 - 1:1000. IHC-P: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

6L11

200 ug/ml

Unconjugated

ACVR2B

activin A receptor type 2B

activin A receptor, type IIB; activin receptor type-2B; ACTRIIB; ActR-IIB; HTX4

Mouse

IgG1

Activin receptor type-2B

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203