alpha Actinin 2 antibody [GT1253]

GeneTex

alpha Actinin 2 antibody [GT1253]

9

Based on sequence homology, this antibody may cross react with ACTN1 protein.

WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

GT1253

1.27 mg/ml

Unconjugated

ACTN2

actinin alpha 2

alpha-actinin skeletal muscle; alpha-actinin-2; CMD1AA; CMH23; F-actin cross-linking protein; MPD6; MYOCOZ; truncated actinin alpha 2

Mouse

IgG1

Alpha-actinin-2

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. [provided by RefSeq]

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203