alpha Actinin 2 antibody [N1N3]
GTX103219
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Porcine, Rat, Zebra Fish
TargetACTN2
Overview
- SupplierGeneTex
- Product Namealpha Actinin 2 antibody [N1N3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.18 mg/ml
- ConjugateUnconjugated
- Gene ID88
- Target nameACTN2
- Target descriptionactinin alpha 2
- Target synonymsCMD1AA, CMH23, CMYO8, CMYP8, MPD6, MYOCOZ, alpha-actinin-2, F-actin cross-linking protein, alpha-actinin skeletal muscle
- HostRabbit
- IsotypeIgG
- Protein IDP35609
- Protein NameAlpha-actinin-2
- Scientific DescriptionAlpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. [provided by RefSeq]
- ReactivityHuman, Mouse, Porcine, Rat, Zebra Fish
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Rodriguez Garcia M, Schmeckpeper J, Landim-Vieira M, et al. Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2. Int J Mol Sci. 2023,24(19). doi: 10.3390/ijms241914572Read this paper
- Flavie Ouali BE, Wang HV. Beta-agonist drugs modulate the proliferation and differentiation of skeletal muscle cells in vitro. Biochem Biophys Rep. 2021,26:101019. doi: 10.1016/j.bbrep.2021.101019Read this paper
- Weber B, Lackner I, Miclau T, et al. Early myocardial damage (EMD) and valvular dysfunction after femur fracture in pigs. Sci Rep. 2021,11(1):8503. doi: 10.1038/s41598-021-86151-zRead this paper
- Cowan J, Longman MR, Snabaitis AK. Regulation of cardiomyocyte DNA damage and cell death by the type 2A protein phosphatase regulatory protein alpha4. Sci Rep. 2021,11(1):6293. doi: 10.1038/s41598-021-85616-5Read this paper
- Masita Silviana N, Andarini S, Lyrawati D, et al. Masticatory Functional Load Increases the mRNA Expression Levels of ACTN2 and ACTN3 and the Protein Expression of α-Actinin-2 in Rat Masseter Muscle. Turk J Pharm Sci. 2021,18(1):28-33. doi: 10.4274/tjps.galenos.2019.53323Read this paper
- Li H, Hou L, Zhang Y, et al. PFN2a Suppresses C2C12 Myogenic Development by Inhibiting Proliferation and Promoting Apoptosis via the p53 Pathway. Cells. 2019,8(9). doi: 10.3390/cells8090959Read this paper
- Foertsch S, Lackner I, Weber B, et al. Sensory contact to the stressor prevents recovery from structural and functional heart damage following psychosocial trauma. Brain Behav Immun. 2019,80:667-677. doi: 10.1016/j.bbi.2019.05.013Read this paper
- Wang L, Zhou X, et al. Qishen Yiqi Dropping Pills Ameliorates Doxorubicin-induced Cardiotoxicity in Mice via Enhancement of Cardiac Angiogenesis. Med Sci Monit. 2019,25:2435-2444. doi: 10.12659/MSM.915194Read this paper
- Roberts MD, Romero MA, Mobley CB, et al. Skeletal muscle mitochondrial volume and myozenin-1 protein differences exist between high versus low anabolic responders to resistance training. PeerJ. 2018,6:e5338. doi: 10.7717/peerj.5338Read this paper
- Kalbitz M, Schwarz S, Weber B, et al. Cardiac Depression in Pigs after Multiple Trauma - Characterization of Posttraumatic Structural and Functional Alterations. Sci Rep. 2017,7(1):17861. doi: 10.1038/s41598-017-18088-1Read this paper
Datasheet
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