Anti-CD81 [CD81K04]

Absolute Antibody

Anti-CD81 [CD81K04]

7

This antibody is specific for a conformational epitope in the extracellular domain of human CD81, a receptor used by hepatitis C virus to infect human hepatocytes.

This antibody has been identified as a potential anti-hepatitis C virus (HCV) agent (Ji et al, 2015). It displays potent and broad-spectrum inhibition of HCV entry in vitro, and has been shown to both prevent HCV infection and limit HCV spread in mice models (Ji et al, 2015) by blocking viral engagement of CD81.The binding specificity of this antibody has been confirmed in FACS analysis (Ji et al, 2015). A Fab fragment of this antibody has been used to determine the crystal structure of CD81K04 binding to the large extracellular loop of CD81 (Bujotzek et al, 2016).

Flow Cytometry, Neutralisation/Blocking, Other Application

crystallisation; neutralisation; FC

Research Use Only

Monoclonal

CD81K04

CD81

CD81 molecule

26 kDa cell surface protein TAPA-1; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; TAPA1; tetraspanin-28; TSPAN28; tspan-28

Human

IgG1

CD81 antigen

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

This antibody was raised by immunising BALB/c and Naval Medical Research Institute (NMRI) mice with CD81 extracellular loop 2 (ECL2) protein or with CHO‐CD81 cells.

-20°C,2°C to 8°C

12352203