Anti-IL-3Ra [57A07], Human IgG1-Fc Fusion,

Absolute Antibody

Anti-IL-3Ra [57A07], Human IgG1-Fc Fusion,

9

This antibody is specific for the alpha subunit of IL-3R

The binding of the original version of this antibody (VHH) to IL3-Ra-expressing viral lipoparticles was characterized in an ELISA (KD 0.783 nM). In a FACS binding assay, this antibody exhibited an EC50 of 0.66 nM, 1.3 nM, and 0.24 nM for MOLM-13, THP-1, and HEK-IL-R3a, respectively, and an IC50 of 1.20 nM in competition against clone 7G3. In its bi-specific constructions with clones 14D09 and 281F12, it served as an anchor (US20220242958).

Flow Cytometry, ELISA

Research Use Only

Monoclonal

57A07

IL3RA

interleukin 3 receptor subunit alpha

CD123; CD123 antigen; hIL-3Ra; IL-3 receptor subunit alpha; IL3R; IL-3R subunit alpha; IL-3RA; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha

Human

IgG1

Interleukin-3 receptor subunit alpha

This chimeric human antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203