Anti-PD-L1 [29E.2A3]

Absolute Antibody

Anti-PD-L1 [29E.2A3]

9

This antibody binds human PD-L1.

The original format of the antibody was able to block the interaction between PD-L1 on the 300.19-hPD-L1 cells and B7-1 on the plate and the interaction between PD-L1 on the 300.19-hPD-L1 cells and PD-1 on the plate (Butte et al., 2008; PMID: 18585785). This antibody was used for detection of PD-L1 expressed in 293T cells by flow cytometry (Broos et al. 2019, PMID: 31394834). The humanized version of the antibody was constructed (AU2019201688). Immunohistochemical staining of frozen tissue sections was performed using the antibody to stain thymic epithelia (Brown et al., 2003; PMID: 12538684).

Flow Cytometry, ImmunoHistoChemistry, Neutralisation/Blocking

Research Use Only

Monoclonal

29E.2A3

CD274

CD274 molecule

B7 homolog 1; B7-H; B7H1; CD274 antigen; hPD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; programmed cell death 1 ligand 1

Human

IgG1

Programmed cell death 1 ligand 1

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203