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Chemical Structure
AZ191 [1594092-37-1]

AG-CR1-3657
Overview
- SupplierAdipoGen Life Sciences
- Product NameAZ191
- Delivery Days Customer10
- CAS Number1594092-37-1
- CertificationResearch Use Only
- Estimated Purity>98%
- Molecular FormulaC24H27N7O
- Molecular Weight429.5
- Scientific DescriptionCell permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50=17nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression. Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene encoding this kinase have been linked to metabolic syndrome. - Chemical. CAS: 1594092-37-1. Formula: C24H27N7O. MW: 429.5. Synthetic. Cell permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50=17nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression. Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene encoding this kinase have been linked to metabolic syndrome.
- SMILESCN1C2=C(C=CN=C2)C(C3=CC=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=N3)=C1
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC51202000