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LEE011 [1211441-98-3]

Research Use Only
SYN-1213
SYNkinase
CAS Number1211441-98-3
Product group Chemicals
Estimated Purity>95%
Molecular Weight434.5
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Overview

  • Supplier
    SYNkinase
  • Product Name
    LEE011 [1211441-98-3]
  • Delivery Days Customer
    10
  • CAS Number
    1211441-98-3
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C23H30N8O
  • Molecular Weight
    434.5
  • Scientific Description
    Chemical. CAS: 1211441-98-3. Formula: C23H30N8O. MW: 434.5. Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. - Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000