IHC-P analysis of human colon polyp using GTX01865 beta Catenin antibody [17C2]. Note the abnormal translocation of the protein to the nucleus.
IHC-P analysis of human colon polyp using GTX01865 beta Catenin antibody [17C2]. Note the abnormal translocation of the protein to the nucleus.
beta Catenin antibody [17C2]
GTX01865
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetCTNNB1
Overview
- SupplierGeneTex
- Product Namebeta Catenin antibody [17C2]
- Delivery Days Customer9
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID17C2
- ConjugateUnconjugated
- Gene ID1499
- Target nameCTNNB1
- Target descriptioncatenin beta 1
- Target synonymsarmadillo; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1; CTNNB; EVR7; MRD19; NEDSDV
- HostMouse
- IsotypeIgG2a
- Scientific DescriptionThe protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203