Caspase 3 antibody
GTX110543
ApplicationsDot Blot, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetCASP3
Overview
- SupplierGeneTex
- Product NameCaspase 3 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:10000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsDot Blot, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.15 mg/ml
- ConjugateUnconjugated
- Gene ID836
- Target nameCASP3
- Target descriptioncaspase 3
- Target synonymsCPP32, CPP32B, SCA-1, caspase-3, CASP-3, CPP-32, PARP cleavage protease, SREBP cleavage activity 1, apopain, caspase 3, apoptosis-related cysteine peptidase, caspase 3, apoptosis-related cysteine protease, cysteine protease CPP32, procaspase3, protein Yama
- HostRabbit
- IsotypeIgG
- Protein IDP42574
- Protein NameCaspase-3
- Scientific DescriptionThis gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimers disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Zhao Z, Yang Q, Zhou T, et al. Anticancer potential of Bacillus coagulans MZY531 on mouse H22 hepatocellular carcinoma cells via anti-proliferation and apoptosis induction. BMC Complement Med Ther. 2023,23(1):318. doi: 10.1186/s12906-023-04120-7Read this paper
- Jia L, Jingzhen Z, Xinliang Y, et al. 4-PBA inhibits endoplasmic reticulum stress to improve autophagic flux in the treatment of protamine/lipopolysaccharide-induced interstitial cystitis in rats. Sci Rep. 2023,13(1):14057. doi: 10.1038/s41598-023-38584-xRead this paper
- Zhao M, Zheng Z, Zhang P, et al. IL-30 protects against sepsis-induced myocardial dysfunction by inhibiting pro-inflammatory macrophage polarization and pyroptosis. iScience. 2023,26(9):107544. doi: 10.1016/j.isci.2023.107544Read this paper
- Demyashkin GA, Vadyukhin MA, Shekin VI. The Influence of Platelet-Derived Growth Factors on the Proliferation of Germinal Epithelium After Local Irradiation with Electrons. J Reprod Infertil. 2023,24(2):94-100. doi: 10.18502/jri.v24i2.12494Read this paper
- Hsia Y, Sivasubramanian M, Chu CH, et al. A Dual Concentration-Tailored Cytokine-Chemo Nanosystem to Alleviate Multidrug Resistance and Redirect Balance of Cancer Proliferation and Apoptosis. Int J Nanomedicine. 2023,18:4253-4274. doi: 10.2147/IJN.S412932Read this paper
- Chen Q, Liao Y, Liu Y, et al. Identification of Fangjihuangqi Decoction as a late-stage autophagy inhibitor with an adjuvant anti-tumor effect against non-small cell lung cancer. Chin Med. 2023,18(1):68. doi: 10.1186/s13020-023-00770-4Read this paper
- Huang C, Lin ZJ, Chen JC, et al. α-Viniferin-Induced Apoptosis through Downregulation of SIRT1 in Non-Small Cell Lung Cancer Cells. Pharmaceuticals (Basel). 2023,16(5). doi: 10.3390/ph16050727Read this paper
- Fletcher E, Miserlis D, Sorokolet K, et al. Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease. Transl Res. 2023,260:17-31. doi: 10.1016/j.trsl.2023.05.002Read this paper
- Hsu PL, Chien CW, Tang YA, et al. Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. Sci Adv. 2023,9(15):eade3422. doi: 10.1126/sciadv.ade3422Read this paper
- Kwon J, Yeh YS, Kawarasaki S, et al. Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes. iScience. 2023,26(3):106161. doi: 10.1016/j.isci.2023.106161Read this paper
Datasheet
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