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ProductsBack/Fibrillarin antibody [38F3]
Blot of yeast protein extract stained with the GTX24566 anti-Gibrillarin Antibody, stained a single band at ~34kDa.
Blot of yeast protein extract stained with the GTX24566 anti-Gibrillarin Antibody, stained a single band at ~34kDa.
Blot of yeast protein extract stained with the GTX24566 anti-Gibrillarin Antibody, stained a single band at ~34kDa.

Fibrillarin antibody [38F3]

GTX24566
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityC. Elegans, Drosophila, Human, Mouse, Plant, Rat, Yeast
TargetFBL
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Overview

  • Supplier
    GeneTex
  • Product Name
    Fibrillarin antibody [38F3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    IF (ICC): 1/1000 - 1/5000 (yeast cells). For IF of mammalian cells, 1/500. WB: 1/2000 (cell lysates) - 1/10000 (nuclear fractions)(ECL). Detects a band of approximately 34 kDa. For other (non-ECL) western detection methods, 1/1000 - 1/5000. To detect mammalian fibrillarin on western blots by ECL, 1/500. Optimal dilutions/concentrations should be determined by the end user.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    38F3
  • Conjugate
    Unconjugated
  • Gene ID2091
  • Target name
    FBL
  • Target description
    fibrillarin
  • Target synonyms
    34 kDa nucleolar scleroderma antigen; 34-kD nucleolar scleroderma antigen; FIB; FLRN; histone-glutamine methyltransferase; Nop1; RNA, U3 small nucleolar interacting protein 1; RNU3IP1; rRNA 2'-O-methyltransferase fibrillarin; U6 snRNA 2'-O-methyltransferase fibrillarin
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP22087
  • Protein Name
    rRNA 2'-O-methyltransferase fibrillarin
  • Scientific Description
    This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
  • Reactivity
    C. Elegans, Drosophila, Human, Mouse, Plant, Rat, Yeast
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly. Bennett CL et al., 2020 Jun, Heliyon
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  • Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development. Behm M et al., 2017 Feb 15, J Cell Sci
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  • Identification and characterization of a novel ubiquitous nucleolar protein NARR encoded by a gene overlapping the rab34 oncogene. Zougman A et al., 2011 Sep 1, Nucleic Acids Res
    Read more