Bio-Connect

Lamin B2 antibody [GT144]

GTX628803
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetLMNB2
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Overview

  • Supplier
    GeneTex
  • Product Name
    Lamin B2 antibody [GT144]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    GT144
  • Concentration
    0.81 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID84823
  • Target name
    LMNB2
  • Target description
    lamin B2
  • Target synonyms
    epididymis secretory sperm binding protein; EPM9; LAMB2; lamin B3; lamin-B2; LMN2; MCPH27
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDQ03252
  • Protein Name
    Lamin-B2
  • Scientific Description
    The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B2. This gene is in a head-to-tail orientation with the gene for the translocase of inner mitochondrial membrane 13 homolog gene. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Excessive reactive oxygen species induce transcription-dependent replication stress.
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  • Differentiation-dependent changes in lamin B1 dynamics and lamin B receptor localization.
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  • The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity. Jevtic P et al., 2019 Jun, EMBO Rep
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  • Andrographolide suppresses the migratory ability of human glioblastoma multiforme cells by targeting ERK1/2-mediated matrix metalloproteinase-2 expression. Yang SL et al., 2017 Dec 1, Oncotarget
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  • RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells. Urban V et al., 2016 Aug 15, J Cell Biol
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