WB analysis of wild-type (WT) and MLKL knockout (KO) HeLa cell extracts using GTX00953 MLKL antibody [GT1191]. Dilution : 1:1000 Laoding : 25microg
![WB analysis of various samples using GTX00953 MLKL antibody [GT1191]. Dilution : 1:1000 Loading : 25microg](https://www.genetex.com/upload/website/prouct_img/normal/GTX00953/GTX00953_20200327_WB_2_w_23053121_117.webp "WB analysis of various samples using GTX00953 MLKL antibody [GT1191]. Dilution : 1:1000 Loading : 25microg")
![Various whole cell extracts (30 microg) were separated by 10% SDS-PAGE, and the membrane was blotted with MLKL antibody [GT1191] (GTX00953) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.](https://www.genetex.com/upload/website/prouct_img/normal/GTX00953/GTX00953_4000000165_20200313_WB_w_23053121_249.webp "Various whole cell extracts (30 microg) were separated by 10% SDS-PAGE, and the membrane was blotted with MLKL antibody [GT1191] (GTX00953) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.")
WB analysis of wild-type (WT) and MLKL knockout (KO) HeLa cell extracts using GTX00953 MLKL antibody [GT1191]. Dilution : 1:1000 Laoding : 25microg
MLKL antibody [GT1191] - Recombinant antibody, KO/KD Validated
GTX00953
Overview
- SupplierGeneTex
- Product NameMLKL antibody [GT1191] - Recombinant antibody, KO/KD Validated
- Delivery Days Customer9
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDGT1191
- ConjugateUnconjugated
- Gene ID197259
- Target nameMLKL
- Target descriptionmixed lineage kinase domain like pseudokinase
- Target synonymshMLKL; mixed lineage kinase domain-like protein
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203