MLKL antibody

Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells.

Cell Death Triggers Induce MLKL Cleavage in Multiple Myeloma Cells, Which may Promote Cell Death.

RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1gamma promote apoptosis and necroptosis. Du J et al., 2021 Dec 3, Nat Commun

Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production. Zu R et al., 2021 Oct 23, Cell Death Dis

Evolutionary Profile for (Host and Viral) MLKL Indicates Its Activities as a Battlefront for Extensive Counteradaptation. Palmer SN et al., 2021 Dec 9, Mol Biol Evol

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury. Tonnus W et al., 2021 Jul 20, Nat Commun

Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex. Seo J et al., 2020 Nov, Cell Death Differ

A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression. Dai J et al., 2020 Apr 24, Cell Death Dis

CK1delta as a potential therapeutic target to treat bladder cancer. Lin YC et al., 2020 Apr 13, Aging (Albany NY)

Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis. Johnston AN et al., 2020 Mar 24, Proc Natl Acad Sci U S A